Cancer stem cells and differentiation therapy
نویسندگان
چکیده
منابع مشابه
Differentiation Therapy with Cancer Stem Cells
Copyright: © 2014 Lin CY. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Recent studies have shown that many tumors contain a small population of cells, termed tumor-initiating cells or cancer stem cells (CSC...
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During metastasis, migrating breast cancer stem cells undergo a loss of polarity leading to an epithelial-to-mesenchymal transition (EMT). Gupta et al. (2009) use this attribute of cancer stem cells to develop a high-throughput screen, which successfully identifies small molecules that specifically inhibit cancer stem cell proliferation through the induction of differentiation.
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Stem cells are cells with the ability to divide for indefinite periods and to give rise to specialized cells. Stem cell therapy has now been emerged as an extraordinary promise to treat a wide range of diseases and conditions. However, except blood stem cell transfer by bone marrow transplant which has been used as an standard practice for more than 50 years, nearly all of therapeutic potenti...
متن کاملDifferentiation of Cancer Stem Cells
Tumors originally develop from normal cells that acquire the ability to grow aberrantly and metastasize to distant organs (Hanahan and Weinberg, 2000). These malignant transformations are considered to be induced by the accumulation of multiple genetic/epigenetic changes (Yamashita et al., 2008b). Although considered monoclonal in origin, cancer is composed of heterogeneous cell populations. Th...
متن کاملDifferentiation of Mouse Embryonic Stem Cells into Hematopoietic Cells
Purpose: Differentiation of Mouse embryonicstem cells into Hematopoietic cells. Materials and Methods: In this study, we used EB formation system for Hematopoietic differentiation of mouse embryonic stem cell (Royan B1) in suspension culture. EBs cultured in medium with Hematopoietic inducer cytokines (SCF, TPO, GMCSF, IL3, Flt3 and EPO) .presence of hematopoietic differentiated cell assessed ...
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ژورنال
عنوان ژورنال: Tumor Biology
سال: 2017
ISSN: 1010-4283,1423-0380
DOI: 10.1177/1010428317729933